1,2-Asymmetric induction in nucleophilic Michael addition reactions of amines under microwave irradiation
Abstract
1,2-Asymmetric induction of up to 76% is observed in the reactions of several amines with the β-substituted acrylic acid ester (S)-1 containing a γ-asymmetric carbon atom in the absence of solvent after 12 min microwave irradiation.