Potentially Carcinogenic Cyclopenta[a]phenanthrenes. Part 12.1 Synthesis of metabolites of the Carcinogen 16,17-Dihydro-11-methoxy-15H-cyclopenta[a]-phenanthrene
Abstract
Starting with 15,16-dihydro-11-methoxycyclopenta[a]phenanthren-17-one, the isomeric 15- and 16-keto analogues have been synthesised along with all three isomeric secondary alcohols, the trans-16,17-diol and a number of other derivatives, some of which are metabolites of the title compound.