The four stereoisomers of 3-hydroxy-2-methylpentanoic acid (1a–d) and the structurally modified acids 1e–j have been synthesised enantiospecifically and converted into p-nitrophenyl ester and thioester derivatives; as the activated derivatives; they are available for investigations into the substrate selectivity of polyketide synthase (PKS) domains.
R. C. Harris, A. L. Cutter, K. J. Weissman, U. Hanefeld, M. C. Timoney and J. Staunton, J. Chem. Res. (S), 1998, 283 DOI: 10.1039/A800584B
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