Insertion of oximic and hydroxamic functions into one simple amino acid creates a new family of powerful chelating agents

Abstract

2-(Hydroxyimino)propanohydroxamic acid, a derivative of alanine in which the amino group has been transformed into oxime and the carboxylic group into a hydroxamic function, is a more powerful chelating agent for Cu²⁺ and Ni²⁺ ions than alanine itself, its oximic or hydroxamic analogues.