Synthesis of 2-deoxy and 2,6-dideoxy glycosides under neutral conditions in LiClO4/Et2O mixtures
Abstract
Glycosides of 2-deoxy and 2,6-dideoxy carbohydrates were built up in high yields and with high stereoselectivity in 0.1 M LiClO4/Et2O mixtures; the glycosidations proceed under neutral conditions and without need for an additional promoter such as a strong Lewis acid, a heavy metal salt or an alkylating reagent.