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Issue 12, 1998
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Universality of LNA-mediated high-affinity nucleic acid recognition

Abstract

LNA (locked nucleic acid) is a novel class of nucleic acid mimic structurally closely resembling RNA; incorporation of three LNA monomers together with six ribonucleotide monomers afforded the first ribo-LNA sequence; unprecedented thermal stabilities of duplexes towards complementary DNA and RNA without compromising base-pairing selectivity were obtained for ribo-LNA, thus establishing the universality of LNA-mediated efficient targeting of natural nucleic acids.

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Article type: Paper
DOI: 10.1039/A801571F
Citation: Chem. Commun., 1998,0, 1247-1248
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    Universality of LNA-mediated high-affinity nucleic acid recognition

    S. K. Singh and J. Wengel, Chem. Commun., 1998, 0, 1247
    DOI: 10.1039/A801571F

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