Rhamnospicamycin 2, a rhamnose analogue (containing adenine, a carbohydrate, an amino acid and a fatty acid) of the naturally occurring combinatorial library spicamycin 1, is prepared from L-rhamnose and shown to be highly cytotoxic towards human myeloma cells (IC50 = 120 nM).
A. Martín, G. W. J. Fleet and T. D. Butters, Chem. Commun., 1998, 2119 DOI: 10.1039/A805878D
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