An artificial receptor for the intermolecular and enantioselective formation of peptide sheets

Abstract

Peptide strands coupled at the C terminus to bis[p-(aminomethyl)phenyl] ether allow in CHCl₃ solution association of lipophilic N-protected peptides with hydrogen bonds in the mode of antiparallel β-sheets; the enantioselectivity observed with a phenylalanine derivative is characterized by a binding constant ratio of around 15.