2,3-Methanoamino acid analogs of Arg stabilize secondary structures of a 13 amino acid peptide in aqueous solution
Abstract
Peptidomimetics 1 and 2 of RN24 (an RNase A C-peptide analog) in which the Arg+-10 residue is replaced by 2R,3S-cyclo-Arg′ and by 2S,3S-cyclo-Arg′, respectively, show less temperature dependence in CD studies than the parent peptide.