The antiviral PMEA is able to mimic the structuring adenosine 5′-monophosphate (AMP2–) in the reactive intermediate, [Cu3(ATP)(AMP)(OH)]–, and to promote the dephosphorylation of ATP; PMEA is about twice as effective as (the ultimate product of this hydrolysis) AMP.
H. Sigel, C. A. Blindauer, C. A. Blindauer, A. Holý and H. Dvořáková, Chem. Commun., 1998, 1219 DOI: 10.1039/A801615A
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