First synthesis of a C-glycoside anologue of a tumor-associated carbohydrate antigen employing samarium diiodide promoted C-glycosylation
Abstract
A hydrolytically stable analogue of the Tn antigen has been efficiently synthesized for the first time employing a SmI2-promoted coupling of the pyridyl sulfone of N-acetylgalactosamine with an aldehydoamino acid derivative.