The reductive coupling of tertiary amides to give enediamines using PhMe2SiLi
Abstract
PhMe2SiLi reacts with tertiary amides to give enediamines, which can be isolated in good yield when the α-carbon is branched; the enediamines can be hydrolysed more or less easily to α-amino ketones, isomerised from Z to E, oxidised to dienediamines and isomerised to amino enamines.