2,2′-Dimethylbiphenyl-6,6′-dicarboxylic acid enforces two attached valine molecules to form up a chiral host lattice

Abstract

Crystals of (R)-valyl 2,2′-dimethylbiphenyl-6,6′-dicarboxylate 3 and (S)-valyl 2,2′-dimethylbiphenyl-6,6′-dicarboxylate 4 are stabilised by a network of inter- and intra-molecular hydrogen bonds; together with the space requirement of the biphenyl core, structures result which contain cavities filled by THF (3) or EtOH molecules engaged in hydrogen bridging (4).