The new and versatile chiral derivatizing agent, α-cyano-α- fluoro-p-tolylacetic acid (CFTA), has been efficiently synthesized in optically pure form by Candida rugosa lipase-mediated kinetic resolution of racemic CFTA ethyl ester, the latter being readily prepared by fluorination of ethyl α-cyano-p-tolylacetate with FClO3.
Y. Takeuchi, M. Konishi, H. Hori, T. Takahashi, Y. Takeuchi, T. Kometani and K. L. Kirk, Chem. Commun., 1998, 365 DOI: 10.1039/A707755F
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