Carboxylate-derived calixarenes with high selectivity for actinium-225
Abstract
The binding properties of two ligands, 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis(carboxymethoxy)calix[4]arene 1 and 5,11,17,23,29,35-hexa-tert-butyl-37,38,39,40,41,42- hexakiscarboxymethoxy)calix[6]arene 2, which show high selectivity for 225Ac3+ (an α-emitter with t1/2 = 10 days) over Na+, K+, Mg2+, Ca2+ and Zn2+ are described.