Asymmetric aldol reaction of 2-cyanopropionates catalysed by trans-chelating chiral diphosphine ligand TRAP–rhodium(I) complex
Abstract
trans-Chelating chiral diphosphine TRAP ligands bearing P-aromatic groups are effective for RhI-catalysed asymmetric aldol reaction of 2-cyanopropionates with an aldehyde to give the corresponding aldol adduct with up to 93% ee.