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Issue 2, 1998
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Assessment of detection methods in trace analysis by means of a statistically based in-house validation concept

Abstract

A matrix-considering in-house validation concept for analytical methods is presented which takes into account the uncertainty due to matrix- and time-induced deviations. It is based on a variance component model for univariate quantitative measurement data that can be adapted to both screening and confirmation methods and to both zero-tolerance and threshold decisions. The model allows the calculation of critical concentrations for given α-errors and the calculation of the corresponding power function to evaluate the performance of an analytical method. The model is applied to a real-life validation experiment.

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Article type: Paper
DOI: 10.1039/A707281C
Citation: Analyst, 1998,123, 173-179

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    Assessment of detection methods in trace analysis by means of a statistically based in-house validation concept

    B. Jülicher, P. Gowik and S. Uhlig, Analyst, 1998, 123, 173
    DOI: 10.1039/A707281C

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