Determination of naproxen with chemiluminescence detection

Abstract

A rapid chemiluminescence method is described for the determination of naproxen, based on the chemiluminescence reaction with cerium(IV) in sulfuric acid medium. The optimum conditions for the chemiluminescence emission were investigated. With the integrated chemiluminescence intensity for 15 s after CeIV injection as a quantitative parameter, naproxen can be determined over the concentration range 100–1000 ng ml^–1 with a detection limit of 15 ng ml^–1 and with RSDs (n = 10) of 0.9% and 1.5% at levels of 1000 and 100 ng ml^–1, respectively. The method was applied to the determination of naproxen in pharmaceutical preparations.