Synthesis of the tetrahydroisoquinoline unit in the AB ring system of the novel antitumor-antibiotic tetrazomine

Abstract

The elaboration of a polysubstituted 7-amino tetrahydroisoquinoline derivative which embodies the central AB ring system of the novel antitumor-antibiotic tetrazomine, employing a highly selective ortho nitration and Jackson tosylamido acetal cyclisation as crucial steps, is reported.