Preparation of carbocyclic, phosphonate analogues of cyclic adenosine monophosphate (cAMP)
Abstract
Compounds 2 and 5 have been synthesised and cyclised to form the cyclic 3′,5′-adenosine monophosphate (cAMP) analogues 3, 6 and 7. In a complementary exercise, cyclopentadiene has been converted into the phosphonic acid 16 in six steps. Compound 16 has been deprotected and cyclised to form the cyclic 3′,5′-adenosine monophosphate (cAMP) analogues 18 and 19.