2-Alkyl-4-arylaminoquinazolines 6 have been prepared by condensation of N-(2-cyanophenyl)amidines 5 with arylamines. The amidines 5 were obtained by thermal rearrangement of N-(2-cyanophenyl)-5-morpholino-v-triazolines 4. The synthesis has been applied to the preparation of 2-alkyl-6-arylaminopurines 12.
E. Erba and D. Sporchia, J. Chem. Soc., Perkin Trans. 1, 1997, 3021 DOI: 10.1039/A703023A
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