Ring-closing metathesis (RCM) of the terminal diene esters 2a,b with the Ru catalyst 1 results in the formation of the 20-, 21-membered macrolactones 3a,b in high yields. RCM of the diene oleate esters 4a,b with 1 gives the 19-, 20-membered macrolactones 5a,b in good yields, while an analogous reaction of the diene β,γ-unsaturated ester 6a gives the 13-membered lactone 7a in low yield.
K. E. Litinas and B. E. Salteris, J. Chem. Soc., Perkin Trans. 1, 1997, 2869 DOI: 10.1039/A702353G
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