Issue 11, 1997

Synthesis of (difluoromethyl)phosphonate azasugars designed as inhibitors for glycosyl transferases

Abstract

Polyhydroxylated pyrrolidines (azasugars) bearing a (difluoromethylene)phosphonate group at the pseudoanomeric position are prepared by nucleophilic opening of arabino-, ribo- and xylo-furanosylamine with diethyl (lithiodifluoromethyl)phosphonate followed by cyclisation of the amino phosphonate products obtained.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1997, 1597-1600

Synthesis of (difluoromethyl)phosphonate azasugars designed as inhibitors for glycosyl transferases

J. Behr, C. Mvondo Evina, N. Phung and G. Guillerm, J. Chem. Soc., Perkin Trans. 1, 1997, 1597 DOI: 10.1039/A700800G

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