Issue 11, 1997
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Preparation and biological activity of tricyclic non-steroidal inhibitors of human steroid 5α-reductase

Andrew D. Abell,   Martin Brandt,   Mark A. Levy  and  Dennis A. Holt  

Abstract

The synthesis and in vitro inhibitory studies against human types 1 and 2 steroid 5α-reductase of a series of 9,10-dihydrophenanthrene-2-carboxylic acids is reported. A (4-carboxy)phenyl substituent at C-7 provides a compound with activity against both isozymes. The structural features responsible for activity are discussed.

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Article information

DOI
https://doi.org/10.1039/A608169J
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1997, 1663-1668

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Preparation and biological activity of tricyclic non-steroidal inhibitors of human steroid 5α-reductase

A. D. Abell, M. Brandt, M. A. Levy<img border="0" src="https://www.rsc.org/images/entities/char_200a.gif" alt=" " xmlns="http://www.rsc.org/schema/rscart38" /> and D. A. Holt<img border="0" src="https://www.rsc.org/images/entities/char_200a.gif" alt=" " xmlns="http://www.rsc.org/schema/rscart38" />, J. Chem. Soc., Perkin Trans. 1, 1997, 1663 DOI: 10.1039/A608169J

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