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Issue 7, 1997
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5-(Alk-1-enyl)-1,2,3,6-tetrahydropyridines as congeners of streptazolin

Abstract

The synthesis of 1,3-dienes which are structurally related to streptazolin, a unique natural compound with antibiotic and antifungal activities, is described. Mimicking of two suggested pharmacophoric units leads to compounds with enhanced chemical stability but without any satisfactory gain in antibiotic activity.

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Article information


J. Chem. Soc., Perkin Trans. 1, 1997, 1009-1012
Article type
Paper

5-(Alk-1-enyl)-1,2,3,6-tetrahydropyridines as congeners of streptazolin

M. Kratzel and A. Weigl, J. Chem. Soc., Perkin Trans. 1, 1997, 1009
DOI: 10.1039/A607309C

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