Derivatives of L-pyrimidylalanine

Abstract

Optically active derivatives of L-isoxazolo[2,3-a ]pyrimidin-4-ylalanine are prepared by the combination of Birch reduction of the phenyl ring of L-phenylalanine, followed by ozonolysis and condensation with 3-amino-5-oxo-4-phenyl-2,5-dihydroisoxazole. Ring cleavage of the five-membered ring by reduction, oxidation and nucleophiles gives pyrimidylalanine derivatives.