Dipeptides bearing nucleobases for the synthesis of novel peptide nucleic acids

Abstract

Three stereoisomers (cis-L, trans-D and cis-D) of N-Fmoc-glycyl-4-(thymin-1-yl)proline and their pentafluorophenyl esters have been prepared for use in the synthesis of novel peptide nucleic acids. In addition, N-Fmoc-glycyl-4-(N⁶-benzoyladenin- 9-yl)proline, N-Fmoc-glycyl-4-(N⁴-benzoylcytosin -1-yl)proline and N-Fmoc-glycyl-4-(N²-isobutyrylguan in-9-yl)proline and their pentafluorophenyl esters of the cis-D series have been synthesized.