Issue 6, 1997

Synthesis of polyfluoroalkylated bicyclic and tricyclic heterocyclic compounds

Abstract

In the presence of base, ethyl 2-hydropolyfluoroalk-2-enoates 1 are converted into polyfluoroalkylated pyrido[1,2-a]pyrimidines 3, 4 by reactions with 2-aminopyridine derivatives 2 and into polyfluoroalkylated pyrimido[2,1-b]benzothiazole 8 or thiazolo[3,2-a]pyrimidine 10, 11 derivatives using 2-aminobenzothiazole 7 or 2-amino-1,3-thiazole 9 derivatives in moderate to good yields. Under different basic conditions, polyfluoroalkenylimidazo[1,2-a]pyridine derivatives 5 or polyfluoroalkylated 1,3-thiazino[3,2-a]benzimidazol-4-one 14 are formed, respectively, from the reaction of 2-aminopyridine derivatives 2 or 2-mercaptobenzimidazole 12 with ethyl polyfluoroalk-2-enoates 1 in moderate yields.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1997, 981-988

Synthesis of polyfluoroalkylated bicyclic and tricyclic heterocyclic compounds

Y. Liu and W. Huang, J. Chem. Soc., Perkin Trans. 1, 1997, 981 DOI: 10.1039/A603071H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements