Jump to main content
Jump to site search

Issue 13, 1997
Previous Article Next Article

Metal complexes of the angiotensin-converting enzyme inhibitor,lisinopril. Solution studies and the crystal and molecular structure ofa dimeric copper(II)–lisinopril complex

Abstract

The binding of the angiotensin-converting enzyme inhibitor lisinopril to zinc(II), copper(II) and nickel(II) has been investigated in solution by pH-metric methods and the crystal structure of the dimeric copper(II)–lisinopril complex, [Cu 2 (HA) 2 (H 2 O) 2 ][ClO 4 ] 2 (H 4 A 2+ = fully protonated lisinopril), has been determined. In the case of the metal ions investigated a major species present in neutral or weakly acidic solution is M(HA) + , the formation constants of which suggest that co-ordination to the metal ions occurs through the amino nitrogen, carboxylate oxygen and the amide oxygen atoms. The crystal structure of the dimeric copper complex shows that each copper is in a distorted square-pyramidal environment in which the basal plane is occupied by carboxylate (Cu–O 1.944 Å) and carbonyl (Cu–O 1.996 Å) oxygens, and an amino group nitrogen (Cu–N 1.989 Å) from one ligand as well as the prolyl carboxylate of another ligand (Cu–O 1.909 Å). An aqua ligand Cu–O (2.355 Å) is axially bonded to each copper.

Back to tab navigation

Article type: Paper
DOI: 10.1039/A701500C
Citation: J. Chem. Soc., Dalton Trans., 1997,0, 2377-2380

  •   Request permissions

    Metal complexes of the angiotensin-converting enzyme inhibitor, lisinopril. Solution studies and the crystal and molecular structure of a dimeric copper(II)–lisinopril complex

    E. Bermejo Gonzalez, E. Farkas, A. A. Soudi, T. Tan, A. I. Yanovsky and K. B. Nolan, J. Chem. Soc., Dalton Trans., 1997, 0, 2377
    DOI: 10.1039/A701500C

Search articles by author

Spotlight

Advertisements