Effect of copper(II) on the aerobic oxidative uptake of iron(II) by horse spleen apoferritin
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Abstract
The interaction of copper(II) with horse spleen apoferritin has been investigated and approximately 16–22 CuII ions are shown to bind relatively tightly to the 24 subunit protein. The bound CuII is shown to have a catalytic effect on the aerobic oxidative uptake of FeII rather than the inhibitory effect that ZnII has. Possible reasons for this are discussed.