Synthesis, crystal structure and biological activity of bis(acetone thiosemicarbazone-S)dichlorodiphenyltin(IV)

Abstract

The reaction between diphenyltin(IV) dichloride and thiosemicarbazide using acetone–ethanol as solvent resulted in the formation of bis(acetone thiosemicarbazone-S)dichlorodiphenyltin(IV), SnPh ₂ Cl ₂ (atsc) ₂ . The crystal structure determination of the compound revealed it to be a monomeric six-co-ordinated organotin(IV) complex. Each of the two atsc functions as a monodentate ligand, co-ordinating to the tin atom through the sulfur atom and conferring a distorted-octahedral geometry upon the tin. The Sn–S bond length is 2.712(1) Å. The antifungal activity of the complex, atsc and SnPh ₂ Cl ₂ against four plant pathogens has been evaluated. The complex displays marked fungitoxicity against these fungi and is more fungitoxic than free atsc and SnPh ₂ Cl ₂ . It has also shown significant cytotoxicity against human colon adenocarcinoma, breast adenocarcinoma, hepatocellular carcinoma and acute lymphoblastic leukaemia.