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Issue 2, 1997
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Glycosidase-catalysed synthesis of oligosaccharides: a one stepsynthesis of lactosamine and of the linear B type 2 trisaccharideα-d-Gal-(1→3)-β-d-Gal-(1→4)-β-d-GlcNAcSEtinvolved in the hyperacute rejection response in xenotransplantation frompigs to man and as the specific receptor for toxin A from Clostridiumdifficile

Abstract

Sequential use of the β-galactosidase from Bacillus circulans and an α-galactosidase from Aspergillus oryzae give the linear B trisaccharide 2, identified as the epitope that binds anti-Gal antibodies during pig-to-man xenotransplantation and as the receptor for toxin A from Clostridium difficile.

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Article type: Paper
DOI: 10.1039/A607255K
Citation: Chem. Commun., 1997,0, 169-170

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    Glycosidase-catalysed synthesis of oligosaccharides: a one step synthesis of lactosamine and of the linear B type 2 trisaccharide α-d-Gal-(1→3)-β-d-Gal-(1→4)-β-d-GlcNAcSEt involved in the hyperacute rejection response in xenotransplantation from pigs to man and as the specific receptor for toxin A from Clostridium difficile

    G. Vic, C. Hao Tran, M. Scigelova and D. H. G. Crout, Chem. Commun., 1997, 0, 169
    DOI: 10.1039/A607255K

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