The asymmetric synthesis of (–)-epibatidine 1, employing as the key step the asymmetric protonation of the achiral lithum enolate of cyclohexanone derivative 5 with chiral β-hydroxy sulfoxide 3b, is described.
H. Kosugi and M. Kato, Chem. Commun., 1997, 1857 DOI: 10.1039/A704779G
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