A study of asymmetric protonation with chiral β-hydroxy sulfoxides. Asymmetric synthesis of (–)-epibatidine
Abstract
The asymmetric synthesis of (–)-epibatidine 1, employing as the key step the asymmetric protonation of the achiral lithum enolate of cyclohexanone derivative 5 with chiral β-hydroxy sulfoxide 3b, is described.