Issue 18, 1997

Chemoenzymatic synthesis of a novel ligand for rhodium-catalysed asymmetric hydrogenation

Abstract

The hydrogenation of alkenes 7a–g using a chiral rhodium catalyst 6 (based on a bicyclo[3.2.0]heptane framework) takes place to give the phenylalanine derivatives 8a–g with remarkably high stereoselectivity (59–92% ee).

Article information

Article type
Paper

Chem. Commun., 1997, 1713-1714

Chemoenzymatic synthesis of a novel ligand for rhodium-catalysed asymmetric hydrogenation

B. Adger, U. Berens, M. J. Griffiths, M. J.K elly, R. McCague, J. A. Miller, C. F. Palmer, S. M. Roberts, R. Selke, U. Vitinius and G. Ward, Chem. Commun., 1997, 1713 DOI: 10.1039/A704136E

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