Partial separation of enantiomeric 1,2-diols via ketal formation with a polymer-supported chiral ketone

Abstract

Partial separations of the (R,R)- and (S,S)-enantiomers of butane-2,3-diol, trans-cyclohexane-1,2-diol and dimethyl tartrate were achieved via ketal formation with a polymer-supported 7-keto steroid; in each case one enantiomer reacted in higher yield than the other and release of the diols from the support gave diol fractions significantly enriched in one enantiomer