Regioselective oxyfunctionalization of peptides by dimethyldioxirane: tertiary C–H ς-bond oxygen atom insertion into leucine derivatives and leucine-containing dipeptides

Abstract

A simple and straightforward approach to selective C–H ς-bond oxygen atom insertion into Leu residues on peptides using dimethyldioxirane is described; this procedure is compatible with Gly, Ala, Val, Ile and Phe residues.