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Issue 11, 1997
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Novel biocatalytic reduction of aryl azides: chemoenzymaticsynthesis of pyrrolo[2,1-c][1,4]benzodiazepineantibiotics1


The chemoselective reduction of aryl azides to aryl amines, and the synthesis of the imine-containing pyrrolo[2,1-c]- [1,4]benzodiazepine DNA-binding antitumour antibiotics by selective biocatalytic reductive cyclization of azido aldehydes, has been achieved by employing baker’s yeast.

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Article type: Paper
DOI: 10.1039/A701249G
Citation: Chem. Commun., 1997,0, 1015-1016

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    Novel biocatalytic reduction of aryl azides: chemoenzymatic synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics1

    A. Kamal, Y. Damayanthi, B. S. Narayan Reddy, B. Lakminarayana and B. S. Praveen Reddy, Chem. Commun., 1997, 0, 1015
    DOI: 10.1039/A701249G

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