Regio- and enantio-selective allylic alkylation catalysed by a chiral monophosphine–palladium complex
Abstract
Allylic alkylation of racemic 1-arylprop-2-enyl acetates
[ArCH(OAc)CH![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
CH
2
] with the sodium enolate of dimethyl
methylmalonate in the presence of a palladium catalyst coordinated with
(R)-2-diphenylphosphino-2′-methoxy-1,1′-binaphthyl
[(R)-MeO-MOP] proceeds with high branch selectivity (90%) to give
chiral products [ArC*H(Nu)CHCH
2
] of up to 87% ee.
CH
2
] with the sodium enolate of dimethyl
methylmalonate in the presence of a palladium catalyst coordinated with
(R)-2-diphenylphosphino-2′-methoxy-1,1′-binaphthyl
[(R)-MeO-MOP] proceeds with high branch selectivity (90%) to give
chiral products [ArC*H(Nu)CHCH
2
] of up to 87% ee.
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