Regioselective palladium-catalysed coupling reactions of vinyl chlorides with carbon nucleophiles

Abstract

Vinyl chlorides bearing methyl groups in the 2-position can be activated catalytically by palladium(0)-complexes of 1,4-bis(dicyclohexylphosphino)butane, the process involving vinyl–allyl isomerization via CH-activation followed by nucleophilic attack of C-nucleophiles on the intermediate palladium–π-allyl species.