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Issue 7, 1997
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Derivatization of Amphetamine and Methamphetamine With1,2-Naphthoquinone 4-Sulfonic Acid Into Solid-phase Extraction Cartridges.Determination of Amphetamine in Pharmaceutical and Urine Samples

Abstract

The derivatization of amphetamine and methamphetamine with 1,2-naphthoquinone-4-sulfonate (NQS) into solid-phase extraction cartridges (C 18 ) is described. Optimum conditions were the use of carbonate–hydrogencarbonate buffer of pH 10, a 10 min reaction time at 25 °C and an NQS concentration of 9.6 × 10 - 3 M. The accuracy and the precision of the method were tested. The results obtained with the proposed liquid–solid procedure were compared with those obtained with a traditional liquid–liquid extraction with hexane–ethyl acetate. The procedure was used to measure amphetamine in pharmaceutical and urine samples

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Article type: Paper
DOI: 10.1039/A701134B
Citation: Analyst, 1997,122, 673-677
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    Derivatization of Amphetamine and Methamphetamine With 1,2-Naphthoquinone 4-Sulfonic Acid Into Solid-phase Extraction Cartridges. Determination of Amphetamine in Pharmaceutical and Urine Samples

    P. Campíns Falcó, C. Molins Legua, A. Sevillano Cabeza and R. Porras Serrano, Analyst, 1997, 122, 673
    DOI: 10.1039/A701134B

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