Potentiometric and Coulometric Titration of 6-Propyl-2-Thiouracil

Abstract

A method for the determination of 6-propyl-2-thiouracil involving its reaction with iodine in an alkaline medium is presented. In volumetric titration with potentiometric end-point detection, the range of determination is 125–500 µmol (21–85 mg). In coulometric titration using biamperometric end-point detection, 0.5–5.0 µmol (0.085–0.85 mg) of 6-propyl-2-thiouracil was successfully determined. The RSD in all applied techniques was <1%. The methods developed were applied to the determination of 6-propyl-2-thiouracil in tablets.