Issue 6, 1996

Electrochemical and peroxidase catalysed oxidation of 1,7-dimethyluric acid and effect of methyl groups on the oxidation mechanism

Abstract

The electrochemical oxidation of 1,7-dimethyluric acid has been studied over a wide pH range of 2.2–10.3 at solid electrodes. Based on the results obtained from linear and cyclic sweep voltammetry, coulometry, spectroscopic studies and various analytical studies, a reaction mechanism has been proposed. The enzymatic oxidation of 1,7-dimethyluric acid has also been found to follow an identical pathway. The products of oxidation have been separated and characterized by using mp, 1H NMR and mass spectra. N-Methylation of the pyrimidine ring of purine causes protonation of nitrogen and affects the oxidation mechanism by not permitting the ring contraction of the diol intermediate.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 2, 1996, 1153-1159

Electrochemical and peroxidase catalysed oxidation of 1,7-dimethyluric acid and effect of methyl groups on the oxidation mechanism

R. N. Goyal, A. K. Jain and N. Jain, J. Chem. Soc., Perkin Trans. 2, 1996, 1153 DOI: 10.1039/P29960001153

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