The coupling efficiency in α-chymotrypsin-catalysed peptide synthesis is greatly improved by the use of activated esters such as the 2,2,2-trifluoroethyl ester as acyl donor instead of the conventional methyl ester; this approach is useful for the incorporation of non-protein amino acids into peptides.
T. Miyazawa, S. Nakajo, M. Nishikawa, K. Imagawa, R. Yanagihara and T. Yamada, J. Chem. Soc., Perkin Trans. 1, 1996, 2867 DOI: 10.1039/P19960002867
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