Parasite glycoconjugates. Part 5. Blockwise approach to oligo(glycosyl phosphates): chemical synthesis of a terminal tris(glycobiosyl phosphate) fragment of Leishmania donovani antigenic lipophosphoglycan

Abstract

The model tetramannosyl triphosphate 7 and the hexaglycosyl triphosphate 8, which is a terminal fragment of the phosphoglycan portion of Leishmania donovani lipophosphoglycan, have been synthesized. Elongation of the chain was performed using the glycosyl hydrogenphosphonate method to couple together two phosphodiester blocks.