Chemistry of insect antifeedants from Azadirachta indica(part 20): synthesis of biologically active, simple analogues of azadirachtin, containing the hydroxytetrahydrofurancarboxylate hemiketal moiety
Abstract
A synthetic route to mimics of the insect antifeedant azadirachtin 1 containing the hydroxytetrahydrofurancarboxylate hemiketal functional moiety has been developed. Two of these compounds, 2 and 11, show significant antifeedant activity against Spodoptera littoralis, although they are not as active as azadirachtin.