Issue 12, 1996

Total synthesis of the virginiamycin antibiotic 14,15-anhydropristinamycin IIB

Abstract

A total synthesis of the virginiamycin 14,15-anhydropristinamycin IIB 16 has been achieved from chiral, non-racemic starting materials, and using a route which features an intramolecular Stille coupling reaction, viz. 14→15, as the key stratagem. The virginiamycin 16 was identical with an authentic sample produced from a Streptomyces fermentation process.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1996, 1315-1317

Total synthesis of the virginiamycin antibiotic 14,15-anhydropristinamycin IIB

D. A. Entwistle, S. I. Jordan, J. Montgomery and G. Pattenden, J. Chem. Soc., Perkin Trans. 1, 1996, 1315 DOI: 10.1039/P19960001315

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