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Issue 10, 1996
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Radical initiated reactions of artemisinin derivatives

Abstract

Heating the propynyldihydroartemisinin derivatives 4 and 5 with Bu3SnH–AIBN in toluene gave the stereoisomers 18 and 20 (5-exo trig products) respectively. The allyl ether 6 gave 21, a 1,2-cis 1,5-trans product under similar conditions, whereas the ether 7 gave two compounds, 22 (1,2-cis 1,5-cis) and 23 (1,2-cis 1,5-trans). The bromo ethers 8–12 gave their corresponding debrominated products whereas the bromo ether 14 and the bromo sulfides 15 and 16 gave the olefin 30.

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Article type: Paper
DOI: 10.1039/P19960001015
J. Chem. Soc., Perkin Trans. 1, 1996, 1015-1020

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    Radical initiated reactions of artemisinin derivatives

    B. Venugopalan, P. J. Karnik and S. Shinde, J. Chem. Soc., Perkin Trans. 1, 1996, 1015
    DOI: 10.1039/P19960001015

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