Synthetic studies towards the clerodane insect antifeedant jodrellin A: preparation of a polycyclic model compound with antifeedant activity

Abstract

Synthetic studies towards the insect antifeedant jodrellin A 1a are reported. This work delineates a synthetic strategy that affords a polycyclic epoxy diacetate model compound 2 which contains most of the structural features found in the natural product. This material was also shown to possess mild insect antifeedant activity against Spodoptera littoralis.