Horseradish peroxidase (HRP)-catalysed enantioselective reduction of racemic hydroperoxy homoallylic alcohols: a novel enzymatic method for the preparation of optically active, unsaturated diols and hydroperoxy alcohols

Abstract

The kinetic resolution of chiral diastereoisomeric hydroperoxy homoallylic alcohols by horseradish peroxidase (HRP)-catalysed asymmetric reduction affords the optically active (R,R) or (R,S) allylic diols and (S,S) or (S,R) hydroperoxy homoallylic alcohols in high enantiomeric excess (up to 99%).