Chelate ring-opening in bis(aminophosphine) complexes of platinum(II) can be controlled by the substituents on N and P under biologically relevant conditions of pH and Cl– concentration; selective and reversible binding to the DNA base guanine can be achieved as well as cytotoxicity towards cancer cell lines.
A. Habtemariam and P. J. Sadler, Chem. Commun., 1996, 1785 DOI: 10.1039/CC9960001785
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